Changes of TCM Syndromes and Laboratory Indices of Diabetic Nephropathy at the End Stage After Hemodialysis

Objective To observe the distribution of TCM syndromes and the changing laws of laboratory indices after hemodialysis of the patients with diabetic nephropathy at the end stage. Methods Totally 84 patients treated by hemodialysis in the diabetic nephropathy group and other nephropathic patients in the non-diabetic-nephropathy group were observed about the difference of distribution of deficiency of anti-pathogenic qi and excess of pathogenic qi and to analyze the changing laws of laboratory indices including creatinine,urea nitrogen,red blood cell (RBC) count,and hemoglobin content on 1 week,1 month,and 2 months after hemodialysis. Results In the diabetic nephropathy group,most patients with deficiency of anti-pathogenic qi were suffering from both qi and yin deficiency,some patients suffering from both yin and yang deficiency,and least patients suffering from spleen and kidney qi deficiency. While those with excess of pathogenic qi were mostly affected by blood stasis,retention of fluid in body,and damp heat. Before hemodialysis,the level of creatinine and urea nitrogen of the diabetic nephropathy group were significantly lower than that of the non-diabetic-nephropathy group (P0.05). One week and one month after hemodialysis,the level of urea nitrogen and creatinine of both groups was significantly lower than before hemodialysis (P0.05). One week after hemodialysis,RBC count and hemoglobin of both groups were lower than those before hemodialysis,and the lowering of hemoglobin was more significant (P0.05). One month after hemodialysis the RBC count and hemoglobin were significantly higher than those one week after hemodialysis(P0.05). Conclusion Diabetic nephropathy is mostly of the yin deficiency and damp heat syndromes. The begining of hemodialysis of diabetic nephropathy is earlier than that of other nephropathic patients. After two months of hemodialysis,the related laboratory indices of diabetic nephropathic patients will be reaching a level of relative stability.