Pharmacokinetic properties of huperzine A sustained release tablets in dogs

Objective:To study the pharmaeokinetic properties of huperzine A sustained release tablets (test tablets)in dogs with immediate release tablets as the reference.Methods:The test(2 tablets)and reference tablets(4 tablets)of huperzine A(200μg)were administered to six dogs by a two-period cross design method. The HPLC method was applied to determine plasma huperzine A.Non-compartment model method was used to cal- culate the pharmacokinetic parameters.Results:T_(max)of huperzine A for the test and reference tablets was(9.33±1.63)and(3.00±0.92)h,respectively;t_(1/2)was(11.01±2.66)and(4.71±1.00)h;C_(max)was(1.95±0.29)and(6.23±0.91)ng·mL~(-1);AUC_(0～t)was(28.29±2.03)and(27.45±1.83)ng·h·mL~(-1).The relative bioavailability of huperzine A sustained release tablets was(103.06±3.72)%.Conclusion:Huperzine A sus- tained release tablets shows characteristics of slow release,and the two preparations were bioequivalent according to statistical analysis.