Pharmacokinetics of Salbutamol-Ethylated β-Cyclodextrins Complexes Sustained Release Tablets in Dogs

The pharmacokinetics and bioavailability of salbutamol ethylated β cyclodextrins complexes sustained release tablets (tested tablets) and salbutamol tablets (reference tablets) were investigated in dogs for single dose according to a randomized crossover design. Drug concentrations in dogs plasma were determined by HPLC with fluorescence detection. The pharmacokinetic parameters for the single dose of tested and reference tablets were T max 7.0±2.6 and 2.2±0.8 h, C max 128.5±24.1 and 201.2±10.6 ng/ml, AUC 1162.2±200.9 and 1054.4±157.3 ng·h·ml -1 , respectively. The relative bioavailability of tested tablets was 110.1% compared with reference tablets. The results showed that the tested tablets had correlation between in vivo absorption and in vitro release.