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2006•Unpublished venueRequires access

Effect of Shenfuning on Proliferation in Glomerular Mesangial Cells

Gang-Qiang Wu

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Abstract

Objective To investigate the effects of Shenfuning on preventing glomerular mesangial cells' proliferation.So as to provide experimental evidence for using Shenfuning to cure chronic kidney disease.Method Glomerular mesangial cells were cultured,TNF-α was used as a stimulation to make the cells proliferate.Then Shenfuning was incubated together at different doses.Cell vitality was evaluated and qualified by MTT.Cell period was analysed by Flow CytoMeter(FCM).Results Glomerular mesangial cells' proliferation were inhibited(P0.05),the DNA diagram of Flow CytoMeter showed that the cell quantity in stage S was reduced(P0.05).Conclusion Shenfuning is able to regulate glomerular mesangial cells' proliferation.

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What this paper is about

Objective To investigate the effects of Shenfuning on preventing glomerular mesangial cells' proliferation.So as to provide experimental evidence for using Shenfuning to cure chronic kidney disease.Method Glomerular mesangial cells were cultured,TNF-α was used as a stimulation to make the cells proliferate.Then Shenfuning was incubated together at different doses.Cell vitality was evaluated and qualified by MTT.Cell period was analysed by Flow CytoMeter(FCM).Results Glomerular mesangial cells' proliferation were inhibited(P0.05),the DNA diagram of Flow CytoMeter showed that the cell quantity in stage S was reduced(P0.05).Conclusion Shenfuning is able to regulate glomerular mesangial cells' proliferation.

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Available abstract

Objective To investigate the effects of Shenfuning on preventing glomerular mesangial cells' proliferation.So as to provide experimental evidence for using Shenfuning to cure chronic kidney disease.Method Glomerular mesangial cells were cultured,TNF-α was used as a stimulation to make the cells proliferate.Then Shenfuning was incubated together at different doses.Cell vitality was evaluated and qualified by MTT.Cell period was analysed by Flow CytoMeter(FCM).Results Glomerular mesangial cells' proliferation were inhibited(P0.05),the DNA diagram of Flow CytoMeter showed that the cell quantity in stage S was reduced(P0.05).Conclusion Shenfuning is able to regulate glomerular mesangial cells' proliferation.

Key concepts: Mesangial cell, Cell growth, Mesangial proliferative glomerulonephritis, Glomerulus, Cell, Stimulation, Cell biology, Chemistry

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