Therapeutic effect of nateglinide combined with insulin glargine on type 2 diabetes mellitus

Objective To observe the therapeutic effect and safety of nateglinide combined with insulin glargine on type 2 diabetes mellitus,as compared with those of insulin Hspart 30 injection.Methods 76 patients with type 2 diabetes mellitus whose blood glucose was not controlled well were randomly divided into two groups,38 patients in trial group were treated with nateglinide combined with insulin glargine,however,the other 38 patients in control group were treated by insulin Hspart 30 injection,with a treatment course of 12 weeks for both groups.The blood sugar(FBG),2-hour postprandial blood sugar(2hPG),hemoglobin sugar(HbA1c),weight index(BMI) were detected before and after treatment,and the incidence of adverse reaction was observed.Results After treatment the levels of FBG,2hPG,HbA1c were significantly decreased,as compared with those before treatment in both groups(P0.01),however,there was no significant difference between two groups(P0.05).After treatment there was no significant change in BMI in trial group,as compared with that before treatment(P0.05),however,which in control group was significantly higher than that before treatment(P0.05),furthermore,there was a significant difference in BMI between two groups(P0.05).The incidence of hypoglycemia in trial group was 13.2%(5/38),which was significantly lower than that [47.4%(18/38)] in control group.Conclusion The nateglinide combined with insulin glargine is effective in treating type 2 diabetes mellitus,with safety and good dependence for patients,without increasing body weight.