On the Effects of Exercises of Different Intensity toward the Serum Levels of Estradiol in Ovariotomized Rats

Objectives:to probe into the effects of the combination of exercises of different intensity and estrogen on the serum levels of E2.Methods:72 female SD rats,3 months of age,were either sham-operated(SHAM) or ovariotomized(OVX) and assigned as following:SHAM,OVX,OVX+ES (ovariotomy with estrogen administration),OVX+EX1,OVX+EX2,OVX+EX3,OVX+EX1+ES,OVX+EX2+ES,and OVX+EX3+ES.The serum levels of estradiol were tested after a period of 1h/day,5 days/week for 8 weeks treadmill training with the speed of 8m/min(EX1)、18m/min(EX2) and 28m/min(EX3) by immunoradiometric assays.Results:The level of E2 in OVX was lower than that in SHAM by 89% (P0.001).Compared with OVX,the concentration of E2 was increased by 41% (P0.05),49% (P0.05) and 17% (P0.05) in groups of OVX+EX1,OVX+EX2 and OVX+EX3 respectively.The concentration of E2 in three combined groups was higher than that in the three single exercise groups but had no significant changes compared with OVX+ES.Conclusion:the ovariotomized rats with only low and moderate exercises exhibited exercise-induced increase in E2,while exercises of three different intensities did not alter the level of E2 in the ovariotomized rats with estrogen administration.