Prospective Randomized Trial in the Evaluation of Combinated Chemotherapy of Low-dose Cisplatin and 5-fluorouracil Versus ELF Chemotherapy in Advanced Cancer

Objective:Objective:The results of a prospectively randomized study from comparison of the combined treatment of low-dose of CDDP and protracted venous infusion of Fluorouracil(L-FP)with the combination of Etoposide,Leucovorin and Fluorouracil(ELF)in advanced gastric cancer were reported.Patients and Methods:Forty nine patients with adennocarcinoma received randomizedly either L-FP (CDDP3.5mg/m2/d,d1-5/w and PVI 5-FU300mg/m2/d,4week)or ELF(Etoposide 100mg/d,d1-3,Leucovorin 200mg/d,d1-5,Fluorouracil 500mg/m2/d,d1-5,every 3 weeks)and analyzed their for survials,response,and toxicities were analyzed.Results:The over-all response rate was 52.2% with L-FP and 31.9% with ELF(P=0.167).Toxicity was both tolerable,and there were no toxic death.The median response duration,the median time to progression,the median survival time was 5.5、7.0、9.0 months with L-PF and 4.0、5.5、7.0 months with ELF.1-year suvival rates was 30.4% and 13.6%,respectively.The difference was statistically significant between the two groups with respect to over-all survial(P=0.032).Conclusion:This study demonstrated that the L-FP was superior to ELF in advanced gastric cancer,and the toxicity was tolerable.