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2005•Medical Journal of Chinese People HeacthRequires access

A study of venlafaxine and paroxetine in the treatment of depressione

Hua Gao

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Abstract

Objective:To compare with efficacy and side effects between venlafaxine and paroxetine in the treatment of depression.Methods:52 inpatients and outpatients with a diagnosis of depression according to the CCMD-3 criteria were involved in this study;they were randomly divided into the venlafaxine group(n = 26) and the paroxetine group(n = 26) for 6 weeks.Effects and side effects were evaluated with HAMD,HAMA, CGI-SI and TESS before and after the treatment.Results: Findings indicated that efficacy of venlafaxine was the similar to those of paroxetine.However,venlafaxine took effect more quickly and its side effects were less than paroxetine.Conclusions:Venlafaxine is an effective and safe antidepressant.It is suggested that venlafaxine could be used as a first-line antidepressant in the treatment of depression for the elder.

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What this paper is about

Objective:To compare with efficacy and side effects between venlafaxine and paroxetine in the treatment of depression.Methods:52 inpatients and outpatients with a diagnosis of depression according to the CCMD-3 criteria were involved in this study;they were randomly divided into the venlafaxine group(n = 26) and the paroxetine group(n = 26) for 6 weeks.Effects and side effects were evaluated with HAMD,HAMA, CGI-SI and TESS before and after the treatment.Results: Findings indicated that efficacy of venlafaxine was the similar to those of paroxetine.However,venlafaxine took effect more quickly and its side effects were less than paroxetine.Conclusions:Venlafaxine is an effective and safe antidepressant.It is suggested that venlafaxine could be used as a first-line antidepressant in the treatment of depression for the elder.

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Available abstract

Objective:To compare with efficacy and side effects between venlafaxine and paroxetine in the treatment of depression.Methods:52 inpatients and outpatients with a diagnosis of depression according to the CCMD-3 criteria were involved in this study;they were randomly divided into the venlafaxine group(n = 26) and the paroxetine group(n = 26) for 6 weeks.Effects and side effects were evaluated with HAMD,HAMA, CGI-SI and TESS before and after the treatment.Results: Findings indicated that efficacy of venlafaxine was the similar to those of paroxetine.However,venlafaxine took effect more quickly and its side effects were less than paroxetine.Conclusions:Venlafaxine is an effective and safe antidepressant.It is suggested that venlafaxine could be used as a first-line antidepressant in the treatment of depression for the elder.

Key concepts: Venlafaxine, Paroxetine, Hamd, Antidepressant, Depression (economics), Venlafaxine Hydrochloride, Psychology, Reuptake inhibitor

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