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Development and validation of the rat model with type 2 diabetes mellitus

Dongwen Wang

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Abstract

Objective To explore a method to develop the type 2 diabetes mellitus (T2DM) rat model. Methods Two-day-old Wistar rats (n=147) were divided into two groups: model and control groups. The modol group rats underwent intraperitoneal injection with 90 mg/kg streptozotocin (STZ). When they had ablacted they were injected with 25 mg/kg streptozotocin(STZ) again. Then these rats were fed the diets enriched with sucrose (20%) , lard(18%) and yolk powder(3%).Another group served as control group. Results Biochemical parameters and morphology proved that the methods could develop the T2DM rat model. Conclusion This method to develop T2DM rat model is high-efficient, stable and quick.

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What this paper is about

Objective To explore a method to develop the type 2 diabetes mellitus (T2DM) rat model. Methods Two-day-old Wistar rats (n=147) were divided into two groups: model and control groups. The modol group rats underwent intraperitoneal injection with 90 mg/kg streptozotocin (STZ). When they had ablacted they were injected with 25 mg/kg streptozotocin(STZ) again. Then these rats were fed the diets enriched with sucrose (20%) , lard(18%) and yolk powder(3%).Another group served as control group. Results Biochemical parameters and morphology proved that the methods could develop the T2DM rat model. Conclusion This method to develop T2DM rat model is high-efficient, stable and quick.

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Available abstract

Objective To explore a method to develop the type 2 diabetes mellitus (T2DM) rat model. Methods Two-day-old Wistar rats (n=147) were divided into two groups: model and control groups. The modol group rats underwent intraperitoneal injection with 90 mg/kg streptozotocin (STZ). When they had ablacted they were injected with 25 mg/kg streptozotocin(STZ) again. Then these rats were fed the diets enriched with sucrose (20%) , lard(18%) and yolk powder(3%).Another group served as control group. Results Biochemical parameters and morphology proved that the methods could develop the T2DM rat model. Conclusion This method to develop T2DM rat model is high-efficient, stable and quick.

Key concepts: Streptozotocin, Intraperitoneal injection, Rat model, Diabetes mellitus, Type 2 Diabetes Mellitus, Medicine, Endocrinology, Internal medicine

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