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The significance of CD55 and CD59 for diagnosing paroxysmal nocturnal hemoglobinuria (PNH)

Weidong Wang

Abstract

Objective:To study the significance of Decay Accelerating Factor(DAF=CD55)?Membrane Inhibitor of reactive Lysis (MIRL=CD59) in the diagnostic of paroxysmal nocturnal hemoglobinuria (PNH). Methods: Flow cytometric analysis of CD55?CD59 was carried to detect the deficiency of membrane protein to the cell surface. Results: The level of CD55(45.94±6.06)%,CD59(46.40±12.36)% of PNH group was significantly lower than that of in AA-PNH CD55(71.00±0.43)%,CD59(84.62±2.08)%,in AA CD55(99.19±0.86)%,CD59(94.42±2.92)% and control group CD55(99.23±0.95)%,CD59(98.56±1.25)%.Conclusion: CD55 and CD59 is a useful target to diagnose and characterize PNH.

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Key concepts: Paroxysmal nocturnal hemoglobinuria, CD59, Decay-accelerating factor, Hemoglobinuria, Eculizumab, Medicine, Internal medicine, Immunology