Effects of Dexamethasone on Hepatic Histomorphology in Rabbits

With the development of animal clinical medicines,dexamethasone is more important in clinical application. The high dose dexamethasone used in long time would damage the liver.25 healthy adult rabbits were randomly divided into 5 groups and administracted with different doses of dexamethasone. After 21 days,rabbits were killed and the livers of rabbits were collected,and pathological lesions of liver were observed under light microscope.The results showed that the cell structure of liver in basic group was clear,there was no denaturation and necrosis. In other groups,the cell structure disorder,the cell swelling,and some erythrocyts were found.