Research on the clinical effect of Chaiyujisheng decoction in dealing with hyperprolactinemia with late menstruation

Objective To observe the effect of Chaiyujisheng decoction week therapy with soothing the liver and invigorating the kidney in the treatment of liver and kidney deficiency type hyperprolactinemia menstruation,and to explore its mechanism of action.Methods 60 cases of hyperprolactinemia late menstruation patients,randomly divided into treatment group(Chaiyujisheng decoction) and control group(bromocriptine) with 30 cases in each group.To observe the clinical curative effect before and after treatment,TCM symptoms,blood prolactin(PRL) and the association between hormone(E_2,LH),and compare the effects of the two therapy.Results Compared with before treatment,index scores of the 2 groups after treatment were improved,the difference was statistically significant(P 0.05);treatment group in improving the menstrual cycle and symptom,breast distending pain,menstrual distending pain in the lower abdomen and other symptoms are significandy better than the control group(P 0.05),the treatment group the total symptom score index was 81.0%,control group 33.0%.Compared with before treatment,the 2 groups after treatment PRL,P,LH,E_2 levels decreased(P 0.05),and the treatment group E_2 levels significantly better than the control group(P 0.05),there were no significant differences in FSH levels in the 2 groups before and after treatment(P 0.05).The 2 group total effectiveness have statistics significance(86.7%vs.73.3%,P 0.05).Conclusion It demonstrated that the Chaiyujisheng decoction week therapy with soothing the liver and invigorating the kidney in treatment of hyperprolactinemia is safe,effective.