Diagnostic value of Cystatin C in renal lesions degree

Objective To investigate diagnostic value of cystatin C in renal lesions degree.Methods 152 cases of patients with nephropathy in our hospital from February 2010 to April 2011 were selected and divided into four groups,renal failure group was group A(50 cases),renal insufficiency decompensate group was group B(40 cases),renal insufficiency was group C(35 cases) and renal failure group was group D(27 cases) in accordance with the glomerular filtration rate(GFR),40 cases of health examination were chosen as the control group,serum CysC of four groups was detected by the particles of latex enhanced immunoturbidimetric assay,enzyme assay was used for the detection of four serum creatinine(Scr),creatinine clearance(Ccr),urea(Urea) level,and analysis of serum CysC and Scr,Ccr correlation.Results CysC,Scr,Urea in group A,B,C,D rised gradually trend,each two had significant difference(P 0.05).Ccr in group A,B,C,D declined gradually,each two had significant difference(P 0.05).CysC in A,B group,the abnormal rate of Scr,Urea were significantly higher than the rate of abnormal(P 0.05).The abnormal rates of CysC,Scr,Urea in group A,B,C,D were no significant difference(P 0.05).CysC,Scr and GFR showed a negative correlation(P 0.05),Ccr and GFR had positive correlation(P 0.05).Conclusion serum CysC is a more accurate,reliable reflect glomerular filtration function,it can be early impairment of renal function,and the operation is simple,without outside interference factors,and is worthy of clinical application.