Investigation the Integrative Therapy Effect of Ambroxol in Patients with Acute Respiratory Distress Syndrome

Objective To investigate the integrative therapy effect of ambroxol which used as continu intravenous pump or intravenous dripping in patients with acute respiratory distress syndrome(ARDS).Methods 63 patients with ARDS were divided randomly into three groups,control group (group A,n=20) and treatment group(group B,n=21),(group C,n=22).Patients in group A were treated with 0.9% NaCl (200 ml),group B with ambroxol (60 mg) plus 0.9 % NaCl (200 ml) intrvenous dripping once a day for 7 days and group C with ambroxol (60 mg) plas 0.9 % NaCl (200 mg) continue pump 24 hours for 7 days.The plasma concentrations of IL-6,IL-8 were measured and blond gas analysis and pulmonary function index were taken before and after the infusion of 5 days and 7 days respectively.Re- sults Compared to group A and group B after treatment with ambroxol in group C,concentrations of IL-6,IL-8,blood gas analysis and pul- monary function index were improved significantly (P0.05 or P0.01).After treatment with ambroxol 7 day in group B,concentrations of IL-6,IL-8 were decresed distinctively(P0.05) compared to before treatment.In group A blood gas analysis and pulmonary function in- dex were much better than those before treatment and in group A(P0.05 or P0.01).Although blood gas analysis improved significant- ly (P0.05),concentrations of IL-6,IL-8 and pulmonary function index hadn't significantly change in group A (P0.05).Conclusion Ambroxol could restrain release of inflammatory media,decrease ALI and improve pulmonary function of patient with ARDS.Continue in- travenous pump is better than intravenous dripping