Clinicopathological analysis of 402 cases with IgA nephropathy

Objective To analyze the clinicopathological characteristics of different types of IgA nephropathy(IgAN). Methods Retrospective analysis of clinical and pathological data of 402 primary IgAN cases diagnosed with renal biopsy was performed.IgAN was divided into 6 types of isolated hematuria(I-H),asymptomatic urinary abnormality(U-ab),recurrent gross hematuria(R-GH),vasculitis(Vas),massive proteinuria(MP) and hypertension(HT). Results U-ab and HT were clinically the most common IgAN.Lee grade Ⅱ and Ⅲ were pathologically the most common IgAN. IgA type,IgA+C3 type and IgA+IgM+C3 type were the most common types on the immunofluorescence. As the deterioration of renal function and the severity of pathological damage increased,the 24-hour urine protein and serum creatinine were increased,but estimated glomerular filtration rate(eGFR) and hemoglobin gradually decreased.eGFR was the greatest factor to impact renal pathological damage. Conclusion The clinical manifestations of IgAN is closely associated with renal pathology.