Change of brain natriuretic peptide levels in patients with congestive heart failure

Objective:To explore the significance of brain natriuretic peptide(BNP) diagnosing patients with congestive heart failure (CHF)and assessing their heart function.Methods:The 40 CHF patients were divided into NYHA classⅠ～Ⅱgroup (8 cases),NYHA class Ⅲ group (20 cases),NYHA class Ⅳ group(12 cases)according NYHA heart function classification.Serum BNP levels in patients on an empty stomach were detected by Triage diagnostic apparatus.Results:The BNP levels increased consecutively with the cardiac function deteriorated from NYHA classⅠto class Ⅳ.The BNP levels in patients with NYHA class Ⅲ[(1601.22 ±108.27) ng/ml vs.(480.53 ±70.18)ng/ml],class Ⅳ[(2101.15 ±81.01) ng/ml vs.(480.53 ±70.18)ng/ml] were significantly higher than that with NYHA classⅠ～Ⅱ(P0.01 all).Two weeks after treatment,the BNP level,LVEF significantly improved in all groups(P0.05～0.01).Conclusion:The determination of BNP levels in CHF patients is helpful to its diagnosis and evaluating its severity.