Analysis of Human Papilloma Viruse Genotypes in Cervical Lesions of 200 Female Patients in Zhangzhou

Objective To study the infection and distribution of human papilloma virus( HPV) genotypes in cervical lesions of female patients in Zhangzhou. Methods HPV genotypes of 200 patients,who had abnormal cervical cells( suspected condyloma acuminatum,CIN and cervical cancer) by cervical biopsy during January 2012 and January2014,were detected with the method of surface plasmon resonance( SPR) technique. Results A total of 84 positive HPV cases were detected among the 200 cases,and the total positive rate was 42. 0%,the rate of single genotype infection to infection cases of HPV was 79. 8%( 67 /84),while the rate of double( 13 cases) and multiple( 4 cases) infections to infection cases was 20. 2%( 17 /84); the rate of high risk of positive subtype and low risk of positive subtype among the total cases were 38. 0%( 76 /200) and 15. 0%( 30 /200) respectively,and the rate to infection cases were90. 5% and 35. 7% respectively; HPV16 was the most frequent high risk of positive subtype,and the rate to all high risk positive subtypes was 39. 5%( 30 /76),and then from high to low,the higher subtypes were followed by HPV81,HPV59,HPV52,HPV53,HPV58 and HPV18; HPV11 was the most frequent low risk of positive subtype,and the rate to all low risk of positive subtypes was 50. 0%( 15 /30),and then followed by HPV54 and HPV6. Conclusion The infected HPV genotype of cervical lesions in women is common in Zhangzhou area with single,double and multiple infections,but the main high risk of infection subtypes are HPV16,HPV81 and HPV52,and the main low risk of subtypes are HPV11,HPV54 and HPV6. The prevention and treatment of cervical lesions should be performed according to the high incidence of HPV infection subtypes.