Prophylactic Effect of Curcumin on Rats Hepatic Fibrosis

Objective:To observe prophylactic effect of curcumin on rat hepatic fibrosis induced by tetrachloride.Methods:Rat models of hepatic fibrosis were constructed by intraperitoneally injection of tetrachloride.Curcumin of 20 mg、10 mg、5 mg per 100 gram weight of rat were given to these rats respectively at the same time.Normal,fibrotic and positive groups were made as controls.After eight weeks,all rats were executed.Serum samples were kept for measuring serum levels of ALT、AST、HA、PC-Ⅲ、TGF-β、TNF-α.Left livers were extirpated for pathologic examination including H.E and Masson stainings.Grade of hepatic fibrosis were evaluate according to SSS system.Results:Serum levels of ALT、AST、HA、PC-Ⅲ、TGF-β、TNF-α of fibrotic group inceased significantly compared with that of normal group,and serum level of these iteme were depressed obviously in curcumin group(P0.05).Staining of H.E and Masson showed that degrees of hepatic fibrosis in curcumin groups were improved obviously compared with that of fibrotic group,and the scores of hepatic fibrosis in curcumin groups reduced significantly.Conclusion:Curcumin Can prevent rat hepatic fibrosis and improve hepatic functions,and Its effect is in dose-dependent.