Caspase-3 in the pathogenesis of multiple mgeloma and its clinical significance

Objective To investigate the role of Caspase-3 in the pathogenesis of Multiple myeloma and its clinical significance.MethodsImmunohistochemistical methods were adopted to examine expressions of Caspase-3 in 28 cases with Multiple myeloma and 10 cases with normal marrow tissue.Results36%of positive expression rate was found in Multiple myeloma,which significantly lower than 70%in normal marrow tissue,P0.05.There were significantly differences between β2 microglobulin and lactate dehydrogenase levels in Caspase-3 positive expression and that in negative expression,P0.05.ConclusionDecreasing of Caspase-3 expression and the incidence of multiple myeloma and the prognosis are closely related.