Analysis of abnormal chromosome in 177 intrauterine prenatal diagnosis

[Objective] To study the frequency of the abnormal chromosome, and to investigate the relationship between the indications of prenatal diagnosis and abnormal karyotypes. [Methods] Cordocentesis and amniocentesis were performed in 177 pregnant women with the indications of prenatal diagnosis during 19~32 gestational weeks. The samples of fetal blood and amniotic fluid were analyed. [Results] 23 abnormal chrosome karyotypes were found in 177 examples and the abnormal rate of abnormal karyotypes was 12.99% (23/177). 7 abnormal karyotypes were found in 37 advanced age pregnant woman and the abnormal rate was 18.93% (7/37). The abnormal rate of pregnant woman or husband chromosome sickness that carried unusual chromosome and malformed fetuses were 33.33%(3/9) and 15.63% (5/32), respectively. [Conclusions] In the pregnant women with prenatal diagnosis, abnormal karyotypes in fetuses are found to be higher in the following situations: pregnant woman or husband chromosome sickness, advanced maternal age, abnormal findings by ultrasound.