Analysis of chromosome karyotypes in 120 cases of intrauterine prenatal diagnosis

Objective: To study the frequency of the abnormal chromosome and to investigate the relationship between the indications of prenatal diagnosis and abnormal karyotypes.Methods: Cordocentesis and amniocentesis were performed in 120 cases of pregnant women with the indications of prenatal diagnosis during 16～36 gestational weeks.The samples of fetal blood and amniotic fluid were analyzed.Results: Seven cases of abnormal chromosome karyotypes were found in 120 cases and the abnormal rate of abnormal karyotypes was 5.83%(7/120).The fetal chromosome examination were performed in 42 advanced age pregnant women and the abnormal rate was 0.There were 8 cases of the pregnant women or their husbands carriers with unusual chromosome and the detection rate of malformed fetuses was 50.00%(4/8).There was 7 cases of fetal anomaly and detection rate of abnormal chromosome was 14.29%(1/7).Conclusion: In the pregnant women with prenatal diagnosis,abnormal karyotypes in fetuses are found to be higher in the following situations: one of the couple with abnormal chromosome,abnormal findings in fetues by ultrasonography.