Effect of platelet-activating factor(PAF)antagonist SRI63-441 on ischemia-reperfusion injury of the myocardium in rats

Objective:TO study the effects of PAF antagonist SRI63-441 on ischemia-reperfusion(I/R)injury of the myocardium.Methods:Rat models of I/R were established with coronary occlusion and reperfusion of the left anterior descending artery (LAD). The rats were randomiy divided into 3groups:control group,reperfusion group and PAF goup. LAD of the rats in control group was not occluded.The rats in PAF group and reperfusion group were given SRI63-441(lmg/kg)and BSA-phosphoric-acid buffer solution by intravenous injection one minute before the occlusion of LAD,respectively.The change of arrhythmia,myocardial infarct size(MIS),superoside dismutase(SOD)activity and malondialdehyde(MDA)level were measured.Results:The MIS,severity of arrhythmia and levels of MDA decreased,while the activities of SOD increased.Conclusion:PAF might be an important mediator involved in myocardial reperfusion injury.PAF antagonist may be useful in the treatment of myocardial I/R injury.