Serum-pharmacological effects of Ruixiang Langdu (Stellera chamaejasme L.)abstract on proliferation of hepatoma cells

SCLA).Methods:SCLA drugserum was derived from mice which were orally preadministrated with different dose of SCLA at different time.The effects of the serum on the proliferation of human hepatoma BEL-7402 cells were observed with MTT assay and clone formation method.Results:After treatment with the drugserum derived at 1,2,3 h from mice pretreated with SCLA(5,10, and 20 g·kg -1 ),the MTT conversion rate and clone formation of BEL-7402 cells were decreased significantly.The drugserum from the mice after 2 h to treated with the SCLA was more effective than others.Conclusion:SCLA had a remarkable inhibitory effects on proliferation of human hepatoma cells,which might be the main anticancer mechanisms of SCLA.