2007•The Chinese Journal of Modern Applied PharmacyRequires access

Effects of the Tibetan Medicine Sazengnia on Blood Rheology in Blood Stasis Rats and Extraneous Thrombosis in Normal Rats

Qiuhong Chen

Abstract

OBJECTIVE To investigate the effect of Sazengnia(SZNA) on blood rheology in blood stasis rats and extraneous thrombosis in normal rats.METHODS The blood stasis model in rats induced by adnephrin.The parameters of blood rheology were measured.Moreover,extraneous thrombosis were evaluated by carotid artery jugular vein circuit in vivo. RESULTS The administration of 5 g·kg-1 SZNA could decrease whole blood viscosity(ηb) and whole blood reduced viscosity(ηr) at shear rates of 10 s-1,60 s-1 and 150 s-1,reduced the aggregation index of RBC(AI)and hemotocrit(HCT) significantly.At the same time,SZNA had the inhibition effect on extraneous thrombosis,but no effects on bleeding time(BT),prothrombin time(PT),thrombin time(TT),fibrinogen(Fib) in normal rats.CONCLUSION SZNA could decrease the blood viscosity in blood stasis rats and inhibit the extraneous thrombosis in remove blood stasis and the anti thrombosis,but no effect on blood coagulation in normal rats.

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Key concepts: Blood stasis, Thrombosis, Blood viscosity, Fibrinogen, Medicine, Hemorheology, Thrombin time, Whole blood