The Expressions and Its Clinical Significance of p53 and CyclinD1 Genes in Human Colon Cancer

Objective To study on the expressions and clinical significance of p53 and cyclinD1 in colon cancer,adenomatous polyps and normal para-cancer colon mucosa.Methods Eighty five cases of colon cancer,18 cases of adenomas and 9 cases of para-mucosa were accumulated and made into two tissue microarrays which containing 72 dost and 104 dots respectively.Expressions of p53 and cyclinD1 proteins were detected by immunohistocheical staining to these microarrays.Results Significant differences were found among colon cancer,adenomas and benign para-cancer mucosa according to the expressions of p53 and cyclinD1(P=0.003,P=0.000).Expressions of p53 and cyclinD1 in cancer were highter than that in adenomatous polyps and normal para-cancer colon mucosa.A significant difference of expressions of p53 in different histological grades(P=0.005) was found in colon cancer.There was no correlation of expression of cyclinD1 with clinicopathological data but clinical stages(P=0.038) in colon cancer was found.Conclusions Overexpression of p53 may be a late event involving in the development of colon cancer an high expressions of cyclinD1 may correlate with the tumorgenesis in colon and may facilitate invasion and progression.