2001•Traditional Chinese Drug Research and Clinical PharmacologyRequires access
Effects of Xuemai Tong on Learning and Memory of Mice
Chen Haoyu
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Abstract
Objective: To evaluate the effects of Xuemai Tong (XT) on memory impairment induced by scopolamine, alcohol and NaNO2 in mice. Methods: Step - down test was applied in scopolamine -induced memory acquisition impairment models and darkness - avoidance test was applied in alco hol- induced memory reappearance impairment models and NaNO2- induced memory retention impairment models. Results: XT could decrease the errors in stepping down in scopolamine- induced models, prolong the latency and decrease the errors in entering the dark room in alcohol - and NaN O2- induced models. XT in large dosage could also increase the brain weight in scopolamine models. Conclusions: XMT can improve memory impairment induced by scopolamine, alcohol and NaNO2 to some extent.