Effect of traditional Chinese medicine compound SMI on function of learning and memory in memory disorder mice

Aim: To observe the effect of compound SMⅠon learning and memory ability in memory disorder mice. Methods: We developed memory disorder mice induced by scopolamine, sodium nitrite and alcohol and used step down test to examine the function of learning and memory in memory disorder mice. Further we measured cholinesterase activity in brain tissue of memory acquired disorder mice induced by scopolamine. Results: Compound SMⅠcould decrease the the total electric shock time in memory acquisition disorder mice (P0.05). SMⅠgroup had longer latency and less error times in memory test in memory consolidation disorder mice (P0.05). In memory retention disorder mice, SMⅠgroup had less error times (P0.05). SMⅠcould decrease the brain cholinesterase activity in memory acquisition disorder mice induced by scopolamine (P0.05). Conclusion:Compound SMⅠcan improve the learning and memory ability of memory disorder mice. It may play a role by decrease the brain cholinesterase activity.