Evaluation of analgesic effects of intravenous parecoxib sodium in patients after minor abdomen surgery

Objective To investigate the efficacy and safety of parecoxib sodium for postoperative analgesia in minor abdomen sugery.Methods 240 patients scheduled for inguinal hernia repair or appendectomy under spinal anesthesia were randomly divided into 3 groups(n =80 each) and received a single injection of 20,40 mg parecoxib sodium(study group PL,PH ) or placebo(control group N ) immediately and 12 h after the operation.The intensity of pain was measured using VAS scores and recorded at 2,4,8,12, 18 and 24 h after operation.The adverse effects and the results of clinical laboratory tests were observed.Results The VAS scored at different time points was significantly lower in the two study groups than in the control group(P0.05 ).Far more patients in the two study groups rated their pain management as good or excellent(P0.05).Compared with group PL,the VAS scores in group PH at 12 h and 24 h were lower and the level of satisfaction was significantly higher(P0.05 ).Conclusion Parecoxib sodium 20 mg or 40 mg given intravenously twice a day has analgesic effect and less side effects on adult patients after minor abdomen surgery.In addition, parecoxib sodium 40 mg is a better pain relief than parecoxib sodium 20 mg.