Determination of serum CA242 for diagnosis and therapy of liver cirrhosis

Objective To elucidate the possibility of CA242 for diagnosis of liver cirrhosis and the relation of CA242 concentration with the situation of liver cirrhosis.Methods ELISA assay was used to detect the concentration of serum CA242 in healthy group and liver cirrhosis group.The tumor markers,AFP,CEA,CA199,and some liver function items,were determined with E170(ROCHE Co.) and 7600-020(HITACHI Co.) instruments.The positive percentage and concentration of the two groups were compared by SPSS 13.0 software,and ROC was used to decide the ability of tumor markers to diagnosis liver cirrhosis.Relations of the concentration of tumor markers with Child-pugh grade of liver cirrhosis were analyzed.Results The concentration of CA242 in two groups was 6.31±7.10 U/ml,7.04±5.17 U/ml,respectively(P 0.05),and the positive percentage was 3.3%,8.8%,respectively(P 0.05).Notably,the CA242 did not have ability to diagnosis liver cirrhosis,and its concentration did not related with Child-pugh grade of liver cirrhosis.Conclusion CA242 should not be used to diagnosis liver cirrhosis and to investigate the situation of liver cirrhosis,while the ratio ALB/GLO, CA199,AFP,CEA,TB and DB may be better items for the above purpose.