Effect of glutamine on secondary endotoxemia in obstructive jaundice rats

Objective To explore the effect of glutamine on secondary with endotoxemia in obstructive jaundice rats,supplying theoretical basis for clinic. Methods Totally 96 healthy SD rats were randomly divided into sham operation group,glutamine group(GLN group) and obstructive jaundice group(OJ group),32 in every group. The contents of endotoxic was detected by chemical group-N=N coloration. Observed the change of endotoxin and in different time,and observed the microanatomy change by HE staining. Results The level in OJ group significant higher than that of sham operation group,The level in OJ group heightend with time,witch was significant deviated with sham operation group in the same time(P0.01). The level of endotoxin in obstructive jaundice could be controlled after glutamine used. Witch had significant difference with that got no therapeutic measure(P0.01).The diameter of bile duct in OJ group and GLN group was obviously bigger than that of sham operation group,and with no difference between the former two groups(P0.05). Conclusion Glutamine could protect and repair the intestinal mucosal barrier,and had the effect to lighten the endotoxemia with lower price. It has high extendable and applicable value.