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[Correlation between ATP bioluminescence tumor chemosensitivity assay and clinical response in ovarian cancer].

Hai-mei Tian, Xiaoyan Shi, Jun Fu, Dong-yan Chao, Kai Zhang, Lingying Wu, Jinwan Wang, Wei Zhang

Abstract

OBJECTIVE: To determine the correlation between results of ATP bioluminescence tumor chemosensitivity assay (ATP-TCA) of human ovarian cancer specimens in vitro and clinical chemo-therapeutic responses of patients. METHODS: Thirty-four freshly taken ovarian cancer specimens (28 cases) and ascites (6 cases) and 9 chemotherapeutic drugs were tested in vitro for cancer chemosensitivity by ATP-TCA. RESULTS: Among the 34 ovarian cancer cases, the efficacy of ATP-TCA is 94.0%, the sensitivity, the specificity, the positive and negative predicting values, and an overall predicting value in vitro and vivo were 90.0%, 91.7%, 94.7%, 84.6% and 90.6%, respectively. CONCLUSION: The results of ATP-TCA assay are correlated well with clinical treatment responses. The assay may be an important and useful method for individual-based chemotherapy of cancers.

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Key concepts: Chemosensitivity assay, Ovarian cancer, In vitro, In vivo, Bioluminescence, Chemotherapy, Cancer, Medicine