Expressions of PCNA,PTTG,c-myc,p53 in Pituitary Adenomas and Their Relationship with the Adenomas Recurrency

Objective To investigate the relationship of proliferating cell nuclear antigen(PCNA),pituitary tumor transforming gene(PTTG),c-myc and p53 with invasiveness,proliferation and recurrency of pituitary adenomas.Methods Immunohistochemical techniques were used to detect the expressions of PCNA,PTTG,c-myc and p53 in 60 cases of pituitary adenomas including 30 cases of invasive tumors,25 cases of non-invasive tumors and 5 cases of recurrent tumors.Results The expressions of PCNA and PTTG in the invasive tumors and recurrent tumors groups were significantly higher than those in the non-invasive tumors group(P0.05).There was insignificant difference in the expressions of PCNA and PTTG between both the of invasive and recurrent tumors groups(P0.05).There was insignificant difference in the expression of c-myc among the invasive,non-invasive and recurrent tumors groups(P0.05).The expressions of p53 was significantly higher in the recurrent tumors groups than that in the invasive and non-invasive tumors groups.Conclusion The expressions of PTTG and PCNA correlates closely with the invasiveness and proliferation in human pituitary adenomas,whereas c-myc and p53 are not ideal indexs of tumor invasiveness.