STUDY ON ENDOTHELIN-1 EXPRESSION AND QUANTITATIVE ANALYSIS IN ASTROCYTOMASLI

Objective:To study endothelin-1 (ET-1)expression in astrocytomas and the relationship between the ET-1quantitative analysis and the estimation prognostic of astrocytomas.Methods:ET-1 positive expression and quantitative analysis were detected in 70 cases with astrocytoma using Streptavidin-Peroxidase method and image analysis technology.Results:The ET-1 expressed in all of astrocytomas, and the ET-1 positive expression were mainly located in the cytoplasm.The positive rates of ET-1 in Ⅳand Ⅲ grade of astrocytoma were significantly higher than the others(p0.05).The results of image analysis on astrocytoma showed that the lower differentiation of astrocytoma, the higher ET-1 quantitative.(P0.01).The ET-1quantitative of astrocytoma were independent survival time of astrocytoma(r=-0.787,P0.01),and dependent the grading of astrocytoma(r=0.863,P0.01)?Conclusion:The ET-1 quantitative analysis may be used as a monitoring index of the estimation prognostic of astrocytomas.