Changes of Serum Concentrations of Matrix Metalloproteinase-9 and CRP in Acute Coronary Syndromes

Objective To study changes of the levels of serum MMP-9 and CRP concentrations of patients with acute coronary syndrome(ACS). Methods 67 patients were selected as ACS group, 20 patients as stable angina (SA) and 20 persons as control. ACS group including 46 patients with unstable angina (UA) and 21 patients with acute myocardial infarction (AMI). The blood samples of the both control and angina group were drown from venous in the morning of the following day after hospitalization, and of the AMI group were drown from venous in the 24 hours after episode. The concentration of MMP-9 was detected by enzyme linked immune sorbent assay (ELISA), and the concentration of C-reactive protein (CRP) was detected by scatter turbidimetry method. The concentration of MMP-9 and CRP in each group was compared. Results ①UA, AMI and SA group were compared with control group, the serum concentration of MMP-9 is (103.456±7.985)ng/ml, (182.667±22.816)ng/ml, (63.375±4.094)ng/ml, (49.050±3.819)ng/ml, respectively, and the concentration of CRP is (6.700±2.450) mg/L, (7.373±4.450) mg/L, (4.100 ±1.125) mg/L, (4.069±0.485) mg/L, respectively, all of indexes are notably increasing(P0.01). ②The relation between MMP-9 and CRP is positive correlation( r=0.757, P0.001). Conclusion Inflammation plays an important role in the origination, pathogenesis and deterioration of ACS. Serum levels of metalloproteinase-9 are significantly elevated in patients with ACS. The variation of MMP-9 concentration of patients with ACS is more remarkable than that of CRP. So MMP-9 can be regarded as a novel marker of inflammation.