2009•Shanxi Yike Daxue xuebaoRequires access
Effect of valsartan on portal hypertension in patients with hepatic cirrhosis
Zhang Suo-juan
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Abstract
Objective To explore the effect of valsartan on hemodynamics and calcitonin gene related peptide(CGRP)in patients with hepatic cirrhosis.MethodsThirty-six patients with hepatic cirrhosis were divided into control group and treatment group.Eighteen patients in control group received routine treatment for 1 month and eighteen patients in treatment group received valsartan 80 mg/d based on routine treatment for 1 month.Diameter of portal or splenic vein and their velocity were measured before and after treatment by color Doppler.The flow volume was calculated.CGRP was simultaneously assessed by radioimmunoassay.ResultsIn treatment group,the diameter of portal or splenic vein reduced after treatment(P0.05),and the mean velocity of portal or splenic vein and the blood flow of portal vein increased(P0.05).The blood concentration of CGRP decreased in treatment group after treatment(P0.05).The above mentioned markers showed no statistically significant difference before and after treatment in control group.ConclusionValsartan can decrease the portal pressure in patients with PHT by reducing blood levels of CGRP.