A comparatire study of risperidone oral solution and risperidone tablets in the treatment of elderly schizophrenia

Objective To compare the efficacy and safety of risperidone oral solution and risperidone tablets in the treatment of elderly schizophrenia.Methods A total of 68 aged patients with schizophrenia were randomly divided into risperidone oral solution group and risperidone tablets group respectively for 8 weeks of treatment.The efficacy was evaluated by Positive and Negative Symptom Scale(PANSS),and the side effects by Treatment Emergent Symptom Scale(TESS).Results Efficacy of two groups started in the 2nd weekend after treatment.Significant differences were found in the reduction of PANSS score between each stage(respectively in the 2nd、4th 、8th week after treatment)and baseline in both groups(P0.01).The effective rate in risperidone oral solution group was 85.7%,and in risperidone tablets group was 87.9%.The efficacy and side effects of two groups at the end of 8th week were mainly myotonia and tremor(20%～25%),then insomnia、constipation and bad appetite(9%～11%) and there were no significant differences between two groups.Conclusion Risperidone oral solution has high safety,good tolerability and similar curative effects to risperidone tablets,and more convenient administration route which is more suitable for elderly patients.