A COMPARATIVE STUDY OF SMALL DOSE KETAMINE, MIDAZOLAM AND PROPOFOL AS CO-INDUCTION AGENT TO PROPOFOL

Intravenous anesthesia is an integral part of modern anesthesia.But till date there is no single intravenous agent which fulfills all the characteristics of an ideal anesthetic agent.Coinduction agents are being used to reduce the dose and adverse effects of a single I.V agent.This comparative study is planned to compare the Hemodynamic Changes and Dose Reduction of Propofol, using small dose of Propofol, Ketamine or Midazolam as co-inducing agents to Propofol.In this Prospective, Randomized, Double Blind, Control study 100 patients of ASA grade I and II, Age 20-40 years of either sex undergoing Elective surgery were randomly divided in 4 groups.SP -Saline (10 mL) + Propofol; KP-Ketamine(0.4 mg/kg) + Propofol; MP -Midazolam(0.3mg/kg)+Propofol; PP -Propofol (0.4mg/kg + Propofol); During study, the Parameters like Induction dose & Prop up dosage requirements & Hemodynamic changes were compared -just after premedication and at just after co induction and then 5, 10, 15 & 20 min after induction.All four groups were comparable with respect to age, sex, weight.The study shows Induction Dose and Total dose of Propofol was least in group KP and prop up dose is also least required in group KP.After induction Heart Rate & MAP decreased in all the groups.Change in MAP & HR was least in Group KP.KEYWORDS: General anesthesia