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2003•Chinese Journal of Geriatric Cardiovascular and Cerebrovascular DiseaseRequires access

Genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) in patients with cerebral infarction

Wen Sheng Sun

Open publisher page 3 citations

Abstract

Objective To study whether polymorphism of MTHFR is associated with susceptibility of human stroke.Methods Whole blood samples from 61 patients and 86 controls matched for age and sex were obtained.The genotype was determined by PCR RFLP protocol.Results For cases and controls C677T allele frequencies were 59.02% and 44.19%,respectively,resulting in P=0.0170. But no difference in A1298C allele between these two groups was found.Meanwhile,combined heterozygosity for both MTHFR mutations was significantly higher in patients(P=0.0086).Conclusion C677T allele and A1298C polymorphism may be associated with stroke,and this is more significant when the 677TT/1298AC genotype is expressed.

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Objective To study whether polymorphism of MTHFR is associated with susceptibility of human stroke.Methods Whole blood samples from 61 patients and 86 controls matched for age and sex were obtained.The genotype was determined by PCR RFLP protocol.Results For cases and controls C677T allele frequencies were 59.02% and 44.19%,respectively,resulting in P=0.0170. But no difference in A1298C allele between these two groups was found.Meanwhile,combined heterozygosity for both MTHFR mutations was significantly higher in patients(P=0.0086).Conclusion C677T allele and A1298C polymorphism may be associated with stroke,and this is more significant when the 677TT/1298AC genotype is expressed.

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Available abstract

Objective To study whether polymorphism of MTHFR is associated with susceptibility of human stroke.Methods Whole blood samples from 61 patients and 86 controls matched for age and sex were obtained.The genotype was determined by PCR RFLP protocol.Results For cases and controls C677T allele frequencies were 59.02% and 44.19%,respectively,resulting in P=0.0170. But no difference in A1298C allele between these two groups was found.Meanwhile,combined heterozygosity for both MTHFR mutations was significantly higher in patients(P=0.0086).Conclusion C677T allele and A1298C polymorphism may be associated with stroke,and this is more significant when the 677TT/1298AC genotype is expressed.

Key concepts: Methylenetetrahydrofolate reductase, Medicine, Genotype, Allele, Loss of heterozygosity, Gastroenterology, Internal medicine, Polymorphism (computer science)

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Genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) in patients with cerebral infarction — Research Paper | ScholarLens