2001•Zhongliu fangzhi yanjiuRequires access
Expression of nm23-H_1 Gene and ras Gene and Their Relations to Lymph Node Metastasis in Human Breast Cancer
Su Guo
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Abstract
Objective To explore the expression of nm23 gene and ras gene and the correlation with lymph node metastasis.Methods By using SP immunohistochemical methods,the nm23 H 1 and rasp21 expression of 76 breast tissues were detected,and the 5 year survival rate were followed up.Results nm23 H 1 gene expression were negative correlation with histologic tumor grade and lymph node metastasis ( P0.005,P0.05 ) ,and its expression was negative correlation with rasp21 expression in breast cancers,the patients with nm23 H 1 gene expression had higher 5 year survival rate than those with rasp21 positive expression.Conclusion nm23 H 1 gene and rasp21 gene were good factor to value prognosis of the cases with breart,and it was ever more effective that both of them were combined.