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DNA Shuffling and Its Application to Biological Pharmaceuticals

LI Xiao-bo

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Abstract

Objective To review the development of DNA Shuffling and the application in biopharmaceuti-cal. It offers the theoretical reference for its further application. Methods The relative literatures were summarized and analyzed. Results and Conclusion DNA Shuffling is a powerful process for directed evolution by recombination in vitro. Mono-gene and multi-gene targeted sequences can be recombined and screened repetitiously to evolve faster by using this method. DNA Shuffling developed rapidly and was applied widely in improving the functions of enzyme, optimisation of pharmaceutical proteins, amelioration of Vaccines and etc.

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What this paper is about

Objective To review the development of DNA Shuffling and the application in biopharmaceuti-cal. It offers the theoretical reference for its further application. Methods The relative literatures were summarized and analyzed. Results and Conclusion DNA Shuffling is a powerful process for directed evolution by recombination in vitro. Mono-gene and multi-gene targeted sequences can be recombined and screened repetitiously to evolve faster by using this method. DNA Shuffling developed rapidly and was applied widely in improving the functions of enzyme, optimisation of pharmaceutical proteins, amelioration of Vaccines and etc.

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Available abstract

Objective To review the development of DNA Shuffling and the application in biopharmaceuti-cal. It offers the theoretical reference for its further application. Methods The relative literatures were summarized and analyzed. Results and Conclusion DNA Shuffling is a powerful process for directed evolution by recombination in vitro. Mono-gene and multi-gene targeted sequences can be recombined and screened repetitiously to evolve faster by using this method. DNA Shuffling developed rapidly and was applied widely in improving the functions of enzyme, optimisation of pharmaceutical proteins, amelioration of Vaccines and etc.

Key concepts: DNA shuffling, Shuffling, Computational biology, DNA, Directed evolution, Biology, Gene, Genetics

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