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STUDY OF THE CYTOKINES OF TNF-α AND IL-10 IN THE DECIDUA AND CHORION IN SPONTANEOUS ABORTION

Hua Yan

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Abstract

Objective:To study the level of tumor necrosis factor-α (TNF-α)and Interleukin-10 (IL-10) in the tissuses of decidua and chorion of first-trimester spontaneous abortion in order to search for the immunological mechanisms of spontaneous abortion.Metheds:50 early pregnancy women at 6～12 weeks gestation were investigated in this study. They were divided into spontaneous abortion group(n=30)and normal early pregnancy group(n=20).TNF-α and IL-10 in the tissuses of decidu and chorion were arlalysed by flow cytometry.Result:The level of TNF-α of decidua and chorion in the early spontaneous abortion group is much higher than that in normal early group.The level of IL-10 of decidua and chorion in the early mormal pregnancy gnoup is greatly higher than that in the spontaneous abortion group.Conclusion:Spontaneous abortion is associated with the imbalance of cytokines at the maternal-fetal interface.

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What this paper is about

Objective:To study the level of tumor necrosis factor-α (TNF-α)and Interleukin-10 (IL-10) in the tissuses of decidua and chorion of first-trimester spontaneous abortion in order to search for the immunological mechanisms of spontaneous abortion.Metheds:50 early pregnancy women at 6～12 weeks gestation were investigated in this study. They were divided into spontaneous abortion group(n=30)and normal early pregnancy group(n=20).TNF-α and IL-10 in the tissuses of decidu and chorion were arlalysed by flow cytometry.Result:The level of TNF-α of decidua and chorion in the early spontaneous abortion group is much higher than that in normal early group.The level of IL-10 of decidua and chorion in the early mormal pregnancy gnoup is greatly higher than that in the spontaneous abortion group.Conclusion:Spontaneous abortion is associated with the imbalance of cytokines at the maternal-fetal interface.

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Available abstract

Objective:To study the level of tumor necrosis factor-α (TNF-α)and Interleukin-10 (IL-10) in the tissuses of decidua and chorion of first-trimester spontaneous abortion in order to search for the immunological mechanisms of spontaneous abortion.Metheds:50 early pregnancy women at 6～12 weeks gestation were investigated in this study. They were divided into spontaneous abortion group(n=30)and normal early pregnancy group(n=20).TNF-α and IL-10 in the tissuses of decidu and chorion were arlalysed by flow cytometry.Result:The level of TNF-α of decidua and chorion in the early spontaneous abortion group is much higher than that in normal early group.The level of IL-10 of decidua and chorion in the early mormal pregnancy gnoup is greatly higher than that in the spontaneous abortion group.Conclusion:Spontaneous abortion is associated with the imbalance of cytokines at the maternal-fetal interface.

Key concepts: Decidua, Abortion, Medicine, Pregnancy, Gestation, Tumor necrosis factor alpha, Early pregnancy factor, Obstetrics

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STUDY OF THE CYTOKINES OF TNF-α AND IL-10 IN THE DECIDUA AND CHORION IN SPONTANEOUS ABORTION — Research Paper | ScholarLens