2004•Chinese Journal of New Drugs and Clinical RemediesRequires access
Pharmacokinetics of gatifloxacin mesylate tablets in healthy volunteers
Wei Li
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Abstract
AIM: To study the pharmocokinetics characteristics of gatifloxacin mesylate tablets in healthy volunteers in order to providing the verification of clinical safety and reasonable application of them. METHODS: Eighteen male subjects received a single oral dose of 400 mg of gatifloxacin mesylate. The plasma concentration of gatifloxacin mesylate was determined by HPLC method. RESULTS: The main pharmacokinetics parameters of gatifloxacin mesylate were as follows: T_ max, C_ max, T__ 12β, AUC_ (0-24) were (1.5±s 0.4) h, (3.4±1.0) mg·L -1,(6.6±1.0) h, (33±10) mg·h·L -1, respectively. CONCLUSION: The pharmacokinetics of gatifloxacin mesylate tablets are similar to those of gatifloxacin hydrochloride. It has advantage of quick absorption, high bioavailability and long mean retention time and inter-individual variability.