Pharmacokinetics of gatifloxacin mesylate tablet in healthy volunteers after multiple dosage administrations

Objective: To study the pharmacokinetics of gatifloxacin mesylate tablet in healthy volunteers after multiple dosage administrations. Methods:Multiple doses of 200 mg gatifloxacin once daily were administered orally for 7 days to 8 healthy volunteers, serum and urine concentrations of gatifloxacin were detected by high performance liquid chromatography. Results:Gati-floxacin was well tolerated in every subject. The concentration-time data were fitted to a two-compartment open model. On days 1 and 7, T max were 1.22 h and 1.35 h respectively, C max were 1.94 mg/L and 2.02 mg/L respectively, t 1/2β were 6.48 h and 7.89 h respectively, AUC 0-∞ were 20.54 mg·h/L and 19.81 mg·h/L respectively, 59.86 % of the given doses were recovered in the urine within 24 h after dosage. Conclusions:Gatifloxacin has favorable pharmacokinetic properties. Gatifloxacin 200 mg once or twice daily dosage may be applied in the treatment of bacterial infections caused by susceptible organisms.