The effects of telmisartan and atorvastatin on UAER and Cys C in older patients with early diabetic nephropathy

Objective To investigate the effects of telmisartan and atorvastatin on the levels of 24 h urine albumin excretion rate(UAER) and serum cystatin C(Cys C) in older patients with early diabetic nephropathy (DN).Methods Sixty five consecutive older patients with early diabetic nephropathy were randomly assigned to telmisartan treatment group(40 mg/d,po),andelmisartan(40 mg/d) plus atorvastatin(20 mg/d,po) treatment group for 12 weeks.The 24h blood pressure monitor,serum lipids,fasting blood glucose(FBG) creatine(Cr),UAER and Cys C were observed pre and post treatment,and compared intra groups.Results After 12 weeks treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP),FBG,UAER,Cys C,triglyeride(TG) were significantly improved in both groups(P0.01).The combination treatment group demonstrated greater improvement in UAER, Cys C,cholesterol(TC),high density lipoprotein(HDL) and low density lipoprotein(LDL),compared with telmisartan treatment group(P0.01).The level of FBG,2 h BG decreased in two groups,but no significant difference was observed(P0.05 ).Conclusion It concluded that applying telmisartan in treatment early diabetic nephropathy could decrease the levels of UAER and improve Cys C,and it had benefit for delaying the progression of early diabetic nephropathy.It would be more remarkable protection effect on kidney once combination with atorvastatin.