Clinical Therapeutic Efficacy of Telmisartan Combined with Sodium Ferulate in Patients with Type 2 Diabetic Nephropathy Early

Objective:To investigate the clinical therapeutic efficacy of telmisartan combined with sodium ferulate in patients with type 2 diabetic nephropathy early(DN).Methods:120 DN patients were randomly divided into treatment group(n=60) and control group(n=60),and basal treatment was given to both groups.The treatment group was treated with telmisartan combined with sodium ferulate.Changes of blood lipid,plasma cystatin C(CysC) levels,endothelin-1(ET-1), nitric oxide(NO),and 24 h urinary albumin excretion rate(UAER),other metabolic parameters were observed,and the clinical effect of two groups were observed and compared after administration of the medicine for 4 weeks.Results:Compared with control group,TC,Cys C,LDL-C,ET-1 and UARE in treatment group were significantly decreased,but plasma NO,HDL-C,GFR levels were significantly increased ( P 0.05 or P 0.01).The curative effects in the treatment group were significantly superior to those in control group( 字2=10.909, P 0.01).Conclusion:Telmisartan combined with sodium ferulate has definite regulatory effect on the blood lipids in patients with DN,can improve endothelial function,decrease proteinuria,protect kindey,increase clinical therapeutic effect,is worth wide spread application.