Serum adiponectin concentrations in patients with essential hypertension

Objective To explore the serum concentrations of adiponectin in patients with essential hypertension, and the relations between adiponectin and blood pressure, tumor necrosis factor- alpha (TNF-α)and leptin. Methods Forty five cases with essential hypertension and forty three healthy control subjects were taken fasting blood samples for measurements of plasma glucose, plasma lipids, insulin, C-peptide, thyroid hormones, TNF-α, leptin and adiponectin. The glucose tolerance was assessed by 75 g oral glucose tolerance test. Results The concentrations of adiponectin in essential hypertensive cases were significant lower than those in the control group (4.15±1.99 vs. 7.04±3.13 μg/ml, P= 0.000). Pearson relation analysis showed that adiponectin levels were negatively and significandy correlated with body-mass index (r= -0.274, P = 0. 038),total cholesterol(r = -0.251, P = 0. 048) in control group, while adiponectin concentration was negatively and significantly correlated with systolic blood pressure (r= -0.356, P=0.016),triglyceride (r= -0.367, P = 0.013), TNF-α(r= -0.298, P=0.047) and triiodothyronine (r= -0. 317, P =0. 034) in essential hypertension group. Multiple regression analysis showed that body-mass index was the independent factor to adiponectin levels, and, SBP and TNF-a were adiponectin independent factors in the essential hypertension group. Conclusion The adiponectin concentration was significant lower in patients with essential hypertension, and there was negative and significant correlation between adiponectin and blood pressure.