Expression of urokinase-type plasminogen activator in epithelial ovarian cancer and its relationship with clinical prognosis

Objective To investigate the expression of urokinase-type plasminogen activator(uPA) in different types of epithelial ovarian tumor and its relationship with the clinical prognosis. Methods SP immunohistochemical staining was used to determine the expression of uPA in 85 cases of ovarian cancer,16 cases of borderline ovarian tumor,39 cases of benign ovarian tumor and 24 cases of normal ovarian tissue.The relationship between the expression of uPA and its differentiation,clinical stage,lymph node metastasis,omental metastasis and survival time were analyzed. Results In 85 cases of epithelial ovarian cancer,the positive expression rate of uPA was 75.3%,significantly higher than those in borderline ovarian tumor(43.8%) ,benign ovarian tumor(35.9%) and normal ovarian tissue(12.5%)(P0.05) .The positive expression rate of uPA in patients with lymph node metastasis,omentum metastasis and the survival time 5 years was significantly higher than that in patients with no lymph node metastasis,with no omentum metastasis and the survival time ≥5 years,respectively(P0.05) . Conclusion The high expression of uPA is related to the occurrence,development,invasion,metastasis and prognosis in epithelial ovarian tumor.