Clinical observation of perioperative mild hypothermia therapy in patients with severe brain injury

Objective To explore cerebral protective effect and clinical significance of perioperative mild hypothermia therapy in patients with severe brain injury. Methods Fifty six patients with severe craniocerebral injury were randomly divided into treatment group(n=28) and control group (n=28).After entered into operation room,mild hypothermia therapy group received cooling 32～35℃,control group received room temperature. Carotid artery and vein blood gas ,electrolyte,ICP,PbtO2,blood pressure,HR during the course of the treatment were observed. Prognosis of patients in two groups was evaluated by GCS. Results The results of the mild hypothermia therapy group were significantly lower than those of the controls (t=14.89,10.19,P0.05) in CEO2 and A-VDO2. The results of the mild hypothermia therapy group were significantly lower than those of the controls (t=2.79,6.89,P0.05) in ICP at 3～7d after operation.The results of the treatment group were significantly lower than those of the controls (t=4.11,6.90,P0.05) in PbtO2 3 days postoperative. Evaluated by GCS score,19 patients recovered well (67.86%),4 patients died(14.29%) in mild hypothermia therapy group,and 11 patients recovered well(39.28%),9 died(32.14%)in control group. There were significantly differences between two groups (χ2=3.42,4.41,P0.05).Conclusions The treatment of perioperative mild hypothermia can decrease ICP,increase PbtO2 in brain injury and protect brain remarkably. Also it can effectively improve prognosis of severe brain injury without serious complications.