Evaluation on diagnostic and prognostic values of m-AST,RBP,PA,ADA and FN in patients with liver diseases

Objective To discuss the diagnostic and prognostic values of serum mitochondrial aspartate amino transferase(m-AST),retinol binding protein(RBP),pre-albumin(PA),adenosine deaminase(ADA) and fibronectin(FN) in patients with liver diseases.Methods The levels of m-AST,RBP,PA,ADA and FN in 132 patients with acute hepatitis,16 patients with severe hepatitis,32 patients with cirrhosis,35 patients with alcoholic hepatitis,68 patients with chronic hepatitis and 92 healthy controls were determined by Hitachi 7180 auto analyzer.The receiver operating characteristic(ROC) curves were created from the results for the calculating of the area under the ROC curve(AUC).Results The levels of m-AST and ADA in patients with acute hepatitis and severe hepatitis were higher than those in healthy controls and the levels of RBP,FN and PA were lower.The anomaly ratio of m-AST was 100%;AUC of m-AST,RBP and PA in acute hepatitis and severe hepatitis were 0.94,0.90,0.85 and 0.96,0.92,0.87 respectively.The level of ADA in liver cirrhosis patients was significantly higher and m-AST was slightly higher than that in healthy controls and the levels of RBP,PA,FN were lower.The anomaly ratio of FN was 100% and its AUC was 0.88,0.66 of ADA,and the others were 0.46-0.47.In alcoholic hepatitis group,m-AST was higher slightly,and FN was lower and the others change slightly.The anomaly ratio of m-AST and FN was high at 98% and 81%;the AUC of m-AST was 0.86 and the others were lower.The m-AST was significantly higher in the chronic hepatitis group,and the anomaly ratios of other values were lower than 60%.All values of AUC were lower.Conclusions The m-AST,RBP,ADA,PA and FN are all valuable markers for acute hepatitis.The m-AST,RBP and PA are valuable in severe hepatitis.The FN and ADA are valuable markers for liver cirrhosis.The m-AST is slightly higher in alcoholic hepatitis and can be used to differentiate with chronic hepatitis.