The significance of fibronectin detection in hepatofibrosis

Objective To investigate the change of serum fibronectin( Fn) level in patients with hepatopathy and the significance of Fn in hepatofibrosis. Methods Serum Fn levels in patients with hepatopathy and healthy controls were determined. Serum total bile acid( TBA) and albumin( Alb) were determined,and the results were analyzed comparatively. Results Serum Fn levels in patients with oxyhepatitis and liver cancer had no statistical significance with those in healthy controls with statistical significance( P 0. 05). Serum Fn levels in patients with chronic moderate hepatitis,chronic severe hepatitis and cirrhosis were lower than those in healthy controls with statistical significance( P 0. 05). Serum Fn levels in patients with cirrhosis were lower than those in other patients with hepatopathy( P 0. 05). Serum Fn levels in patients with alcohol cirrhosis and virus cirrhosis had no statistical significance( P 0. 05). Serum Fn levels in cirrhosis patients with complications,such as peritonitis, hemorrhage of digestive tract and hypersplenia,decreased significantly than those without complications( P 0. 05). Serum Fn and TBA in healthy controls and patients with oxyhepatitis and liver cancer had no correlation( P 0. 05),and had negative correlation between patients with chronic moderate hepatitis,chronic severe hepatitis and cirrhosis( r =-0. 593,-0. 677 and-0. 714,P 0. 05). Serum Fn had no correlation with Alb( P 0. 05). Conclusions Serum Fn can reflect the function of hepatocyte in a certain extent,and has certain reference significance in the diagnosis of hepatofibrosis especially cirrhosis and cirrhosis with infection. The diagnostic accuracy and reliability of Fn determination with TBA and Alb can be obviously improved.